منابع مشابه
Tissue Profiling by Mass Spectrometry
Matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) has become a valuable tool to address a broad range of questions in many areas of biomedical research. One such application allows spectra to be obtained directly from intact tissues, termed “profiling” (low resolution) and “imaging” (high resolution). In light of the fact that MALDI tissue profiling allows over a thousand...
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Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5/A14, 625 00 Brno, Czech Republic Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 3/A1, 625 00 Brno, Czech Republic Department of Analytical Chemistry, Nutrition and Food Science, Faculty of Chemistry, University of La Laguna, Campus de Anchieta, 38071 La Laguna, Tenerife, Spain ...
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Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative pathologies characterized by the formation in the central nervous system of the amyloid protein PrPSc, which derives from a cellular precursor called PrPc. Epidemiological and laboratory studies have shown that in species where the PrPc gene is polymorphic, the genotype composition is an important fac...
متن کاملReproducibility in protein profiling by MALDI-TOF mass spectrometry.
BACKGROUND Protein profiling with high-throughput sample preparation and MALDI-TOF MS analysis is a new potential tool for diagnosis of human diseases. However, analytical reproducibility is a significant challenge in MALDI protein profiling. This minireview summarizes studies of reproducibility of MALDI protein profiling and current approaches to improve its analytical performance. METHODS T...
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Mass spectrometry-based tissue profiling and imaging are technologies that allow identification and visualization of protein signals directly on thin sections cut from fresh frozen tissue specimens. These technologies were utilized to evaluate protein expression profiles in the normal mouse prostate during development (1-5 weeks of age), at sexual maturation (6 weeks of age), and in adult prost...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2005
ISSN: 1535-9476
DOI: 10.1074/mcp.r500006-mcp200